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Quercetin has potent anticarcinogenic properties and known to contribute as apoptosis inductor whereby it decreases the growth of tumor in and brain, liver, colon, and other tissues and inhibits the spread of malignant cells.[42,43] Cruz-Correa et al. studied the combination treatment with curcumin and quercetin on familial adenomatous polyposis (FAP) patients. The patients were administered with curcumin 480 mg and quercetin 20 mg orally 3 times a day for mean of 6 months. At the end of the study, curcumin and quercetin reduced the number and size of ileal and rectal adenomas with minimal adverse effects.[44]




Android В» Page 8 of 84 В» FAP NATION



Quercetin has been reported to have features of neuroprotection in rat brain when used in combination with fish oil. Subsequently, it has also been reported to show beneficial effects against neurodegenerative diseases.[56,58] Quercetin with its radical scavenging potential is said to be capable of preventing cancer which is induced by oxidative stress.[58]


Quercetin supplementation (150 mg/day) reduced systolic blood pressure and plasma oxidized LDL concentrations in overweight subjects in 5 weeks double-blind trial.[31] In another study, quercetin does not affect the fasting serum concentration of total cholesterol and reduced the levels of high-density lipoprotein cholesterol and apoA1 in apoϵ4 carrier and reduced blood pressure in obese carriers of the apo ϵ3/ϵ3 genotype.[59] Brüll et al. studied the effect of quercetin 162 mg/day on overweight-to-obese patients with prehypertension and Stage I hypertension and concluded that quercetin supplementation lower ambulatory blood pressure in patients with hypertension.[60] Quercetin 500 mg/day also reduced systolic blood pressure in women with Type 2 diabetes.[61] Cruz-Correa et al. studied the effect of quercetin (20 mg) and curcumin (480 mg) on FAP in five patients and found to be effective against FAP.[44] Combination of quercetin (20 mg) and curcumin (480 mg) showed benefaction effect in patient who dependent cadaveric kidney recipients.[62]


With its striking three-leg mounting, the D-30 can be rapidly traversed through 360 degrees. Although no longer manufactured in the nations of the former Soviet Union, the D-30 is still manufactured internationally and is in service in more than 60 countries' armed forces.


The gun remains a mainstay of artillery forces in developing countries and was deployed in the war in Afghanistan. Soldiers from several western armies have been trained on the D-30 by various user nations in order to be able to train Afghan soldiers on it.


Soviet 122 mm howitzers used different ammunition to 122 mm guns, although there was some compatibility. In the case of ammunition for the D-30, the standard 122 mm howitzer shell weight of 21.8 kg was retained, with a metal cartridge case holding variable propelling charges. Cartridge and shell are loaded separately; this means that the shells have to be hand-rammed by a man to the right of the breech with a ramming rod. The D-30 could fire the older M-30 ammunition; however, new shells were also introduced, eventually including a rocket-assisted projectile with a range of 21.9 km. The M-30's range of propelling charges, comprising base and eight increments, was replaced by a new set comprising base and four increments; single base propellant was retained. A more effective High Explosive (HE) shell was developed, as well as smoke, illumination and chemical filled projectiles.


Rick and Morty porn parodies also blasted off this year, and the passing fascination with Fidget Spinners caused a big spike in porn searches (and some very creative amateur videos). Lots of people discovered ASMR (Autonomous Sensory Meridian Response) porn this year, too and liked what they heard. We also saw major increases in the popularity of Hentai (nsfw) around the world, and fans of cheerleaders caused a massive boost in these searches as well.


In a retrospective study, outcomes were compared in 189 patients 80 years or older with Alzheimer disease who had used either donepezil or standardized G. biloba extract (EGb 761) for 12 months. No differences were noted in cognitive decline, as measured by MMSE. Rates of discontinuation because of lack of effect were similar between groups; however, more donepezil patients discontinued because of adverse effects.(Rapp 2018) Secondary analysis of data from a randomized controlled trial that enrolled 150 patients with Alzheimer's disease or mild cognitive impairment found no significant difference in 6 neuropsychological outcome measures between ginkgo biloba extract and donepezil when administered alone or in combination for 6 months. Similar improvement was seen across all 3 groups. Only Mini Mental State Examination (MMSE) at month 1 was significantly lower with donepezil alone (P=0.019); otherwise, between-group comparisons were similar at months 1, 3, and 6 for MMSE, cognition, activities of daily living, geriatric depression, neuropsychiatric inventory, and quality of life. Additionally, changes in significant discriminative brain regions were observed according to treatment group that were found to correlate to specific functional magnetic resonance imaging metrics. For example, changes in 2 specific metrics were positively correlated in the right gyrus rectus in gingko patients (P=0.03) and negatively correlated in the left superior cerebellum gyrus in donepezil patients (P=0.01).(Zheng 2021) In Alzheimer patients, a meta-analysis that included data from 6 double-blind, randomized, placebo-controlled and 1 donepezil comparator trial (N=939) reported significant improvements in cognitive function (relative risk [RR],1.983; 95% confidence interval [CI], 1.521 to 2.585; P


In the Impact of Cholinergic Treatment Use (ICTUS) study (N=828), 96.5% of patients received cholinesterase inhibitor therapy alone and 3.5% received ginkgo in combination with cholinesterase inhibitors. Improvements in MMSE score were observed in the combination therapy group; however, changes in the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) subscale score and the Activities of Daily Living score were not significantly different. Patients receiving combination therapy were found to have a significantly higher education level (P=0.01) and lower baseline ADAS-Cog score (P


Evidence is lacking regarding the role of gingko in the management of menopausal symptoms or sexual function in women.(Reid 2014, Wheatley 2004) Clinical trials with small sample sizes have produced varying and equivocal results regarding effects of ginkgo on sexual function.(Ashton 2000, Boone 2005, Oh 2006, Ozgoli 2009, Wheatley 2004) In one study (N=99), G. biloba extract had a small but significant facilitatory effect on physiological, but not subjective, sexual arousal compared to placebo. The long-term effects of G. biloba extract on sexual function were then assessed in 68 sexually dysfunctional women randomly assigned to 8 weeks of treatment with G. biloba extract 300 mg/day, placebo, sex therapy alone, or sex therapy in combination with G. biloba extract. G. biloba extract was determined to be no more effective than placebo.(Meston 2008) Canadian Society of Obstetricians and Gynaecologists revised clinical practice guidelines on managing menopause (2014) do not recommend ginkgo for reducing menopausal symptoms, based on a lack of evidence supporting clinical benefit.(Reid 2014)


A Cochrane meta-analysis of 4 clinical trials (N=1,543) conducted up to March 2012 in adults with tinnitus, either as the primary complaint or as a component of cerebral insufficiency, showed no evidence that supplemental ginkgo was effective. In patients with vascular dementia or Alzheimer disease and tinnitus, a small but statistically significant reduction in tinnitus was observed.(Hilton 2013) Similar results were reported in another systematic review and meta-analysis of 4 randomized placebo-controlled clinical trials (N=1,246). No significant benefit was found for ginkgo on the severity or intensity of tinnitus or quality of life.(Kramer 2018) A literature review reports equivocal results,(Mahmoudian-Sani 2017) and a small (N=56) clinical study found no effect of ginkgo supplementation on idiopathic sudden sensorineural hearing loss for most outcomes measured, except for speech discrimination.(Koo 2016) 041b061a72


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